结果
12例患儿（9名女性）的平均年龄和体重分别为：9.2 ± 4.8岁和33.4 ± 15.4公斤。行射频消融的SVT患儿比行缺陷封堵的ASD患儿年龄要更大，体重更重（见表1）。依托咪酯麻醉诱导前注射吗啡和咪唑安定的平均剂量见表1。
从术前用药到获得血管通道（麻醉时间）的平均时间为 50.3 ± 15.7 分钟，从皮肤准备到开放血管通道、血管内置管的平均时间为 25.1 ± 15.5 分钟。再次测量血流动力学参数的平均时间为 3.5 ± 1.1 分钟。
所有患者血流动力学和血氧饱和度的数据见表2，依托咪酯诱导后所有的参数都没有明显的变化。因为ASD和SVT患儿的例数小，我们对每一个分组进行了单独的分析，也没有显示在使用依托咪酯后，患儿的血流动力学和血氧饱和度参数发生明显的变化（见表3）。此外，方差分析也提示，在使用依托咪酯之前和之后，两组间没有明显的差异（所有分析结果，P > 0.01）。
图1显示了心率，肺动脉压，主动脉压，肺血管阻力和全身血管阻力的平均绝对变化百分比。尽管肺血管阻力和全身血管阻力的平均绝对变化百分比分别为28%和23%，但因为患儿间的个体差异，这种变化在统计学上没有意义。
在泮库溴铵注射之前，患儿没有发生气道阻塞或肌阵颤，但一例患儿因为发生低通气而需要气囊面罩通气。所有病例都获得了完整的数据测定。所有手术顺利进行，所有患儿在次日离院。
华译网上海翻译公司曾经翻译过大量有关依托咪酯诱导对小儿患者血流动力学的影响资料文件，Beijing Chinese Subtitling Translation Service Agency has translated many technical documents about Hemodynamic Responses to Etomidate on Induction of Anesthesia in Pediatric Patients.
Result
Mean age and weight for the 12 patients (9 females) was 9.2 ± 4.8 years and 33.4 ± 15.4 kg. SVT patients undergoing radiofrequency catheter ablation were older and larger than those undergoing catheterization for ASD device closure (Table 1). The average amount of morphine and midazolam administration for sedation before induction with etomidate is also shown in Table 1.
The mean time from premedication to obtaining vascular access (anesthesia time) was 50.3 ± 15.7 min. The mean time from skin preparation to obtaining vascular access by the catheterizer was 25.1 ± 15.5 min. The mean time to remeasure the hemodynamic profile was 3.5 ± 1.1 min.
The hemodynamic and oxygen saturation data for all patients are shown in Table 2; there were no significant differences before and after etomidate administration in any of the variables. Because the numbers of ASD and SVT patients were small, we performed a separate analysis in each subgroup and could not detect differences in hemodynamic or saturation variables before and after etomidate administration (Table 3). In addition, analysis of variance indicated no significant differences in the amount of change pre- versus post-etomidate between the two groups (all P > 0.01).
Figure 1 presents graphically the mean absolute percent change for heart rate, PAP, AOP, PVR, and SVR. Although the mean absolute percent changes in PVR and SVR were 28% and 23%, respectively, the change was not significant because of the variability among patients.
None of the patients had airway obstruction or myoclonus after etomidate before pancuronium administration, but one patient required assistance with gentle bag/mask ventilation because of hypoventilation. Complete data measurements were obtained for all patients. Subsequent procedures were uneventful and all patients were discharged the following day.
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